Hermes Trismegistus Syllabification: (Her·mes Tris·me·gis·tus)Pronunciation: /ˌtrisməˈjistəs/Definition of Hermes Trismegistus a legendary figure regarded by Neoplatonists and others as the author of certain works on astrology, magic, and alchemy. Origin:Latin, 'thrice-greatest Hermes', in reference to Thoth, identified with HermesHermes Trismegistus in other Oxford dictionaries Definition of Hermes Trismegistus in the British & World English dictionary