Guiana Syllabification: (Gui·a·na)Pronunciation: /gēˈänə, gīˈanə/Definition of Guiana a region in northern South America, bounded by the Orinoco, Negro, and Amazon rivers and the Atlantic Ocean. It now includes Guyana, Suriname, French Guiana, and the Guiana Highlands. Guiana in other Oxford dictionaries Definition of Guiana in the British & World English dictionary