Guayaquil Syllabification: (Gua·ya·quil)Pronunciation: /ˌgīəˈkēl/Definition of Guayaquil a seaport in western Ecuador, the country’s principal port and second largest city; population 2,223,200 (est. 2008). Guayaquil in other Oxford dictionaries Definition of Guayaquil in the British & World English dictionary