Cherokee Syllabification: (Cher·o·kee)Pronunciation: /ˈCHerəkē/Definition of Cherokee noun (plural same or Cherokees) 1a member of an American Indian people of the southeastern US, now living on reservations in Oklahoma and North Carolina. 2the Iroquoian language of the Cherokee, which has had its own script since 1820. adjective relating to the Cherokee or their language. Origin:from Cherokee tsarakiCherokee in other Oxford dictionaries Definition of Cherokee in the British & World English dictionary