Arachne Syllabification: (A·rach·ne)Pronunciation: /əˈraknē/ Greek MythologyDefinition of Arachne a woman of Colophon in Lydia, a skillful weaver who challenged Athena to a contest. Athena destroyed Arachne’s work and Arachne tried to hang herself, but Athena changed her into a spider. Origin:from Greek arakhnē 'spider'Arachne in other Oxford dictionaries Definition of Arachne in the British & World English dictionary