Antigua Syllabification: (An·ti·gua)Pronunciation: /anˈtēgwə, -ˈtigwə/ (also Antigua Guatemala /ˌgwätəˈmälə/)Definition of Antigua a town in the central highlands of Guatemala; population 54,100 (est. 2009). Antigua in other Oxford dictionaries Definition of Antigua in the British & World English dictionary