Albuquerque Syllabification: (Al·bu·quer·que)Pronunciation: /ˈalb(y)əˌkərkē/Definition of Albuquerque city in central New Mexico, on the Rio Grande; population 521,999 (est. 2008). It is the largest city in the state. Albuquerque in other Oxford dictionaries Definition of Albuquerque in the British & World English dictionary