insane
Pronunciation: /ɪnˈseɪn/
adjective
- in a state of mind which prevents normal perception, behaviour, or social interaction; seriously mentally ill: he had gone insane
- (of an action or quality) characterized or caused by madness: his eyes were glowing with insane fury
- extremely annoyed: a fly whose buzzing had been driving me insane
- extremely foolish; irrational: she had an insane desire to giggle

Origin:
mid 16th century: from Latin insanus, from in- 'not' + sanus 'healthy'