zygotePronunciation: /ˈzʌɪgəʊt/Definition of zygote noun Biology a diploid cell resulting from the fusion of two haploid gametes; a fertilized ovum. Derivatives zygoticPronunciation: /-ˈgɒtɪk/ adjective Origin: late 19th century: from Greek zugōtos 'yoked', from zugoun 'to yoke'zygote in other Oxford dictionaries Definition of zygote in the US English dictionary