zidovudinePronunciation: /zɪˈdɒvjʊdiːn, -ˈdəʊ-/Definition of zidovudine noun [mass noun] Medicine an antiviral drug used in the treatment of AIDS. It slows the growth of HIV infection in the body, but is not curative. A thymidine derivative; chemical formula: C10H13N5O4 Origin: 1980s; arbitrary alteration of azidothymidinezidovudine in other Oxford dictionaries Definition of zidovudine in the US English dictionary