xerodermaPronunciation: /ˌzɪərə(ʊ)ˈdəːmə, ˌzɛ-/Definition of xeroderma noun [mass noun] any of various diseases characterized by extreme dryness of the skin, especially a mild form of ichthyosis. Origin: mid 19th century: modern Latin, from xero- 'dry' + Greek derma 'skin'xeroderma in other Oxford dictionaries Definition of xeroderma in the US English dictionary