ventriclePronunciation: /ˈvɛntrɪk(ə)l/Definition of ventricle noun Anatomy a hollow part or cavity in an organ, in particular: each of the two main chambers of the heart, left and right. each of the four connected fluid-filled cavities in the centre of the brain. Derivatives ventricularPronunciation: /-ˈtrɪkjʊlə/ adjective Origin: late Middle English: from Latin ventriculus, diminutive of venter 'belly'ventricle in other Oxford dictionaries Definition of ventricle in the US English dictionary