ureaPronunciation: /jʊˈriːə, ˈjʊərɪə/Definition of urea noun [mass noun] Biochemistry a colourless crystalline compound which is the main nitrogenous breakdown product of protein metabolism in mammals and is excreted in urine. Chemical formula: CO(NH2)2 Origin: early 19th century: modern Latin, from French urée, from Greek ouron 'urine'urea in other Oxford dictionaries Definition of urea in the US English dictionary