tyrosinasePronunciation: /ˈtʌɪrəsɪneɪz, tʌɪˈrɒs-/Definition of tyrosinase noun [mass noun] Biochemistry a copper-containing enzyme which catalyses the formation of quinones from phenols and polyphenols (e.g. melanin from tyrosine). Origin: late 19th century: from tyrosine + -asetyrosinase in other Oxford dictionaries Definition of tyrosinase in the US English dictionary