trophoblastPronunciation: /ˈtrɒfə(ʊ)blast, ˈtrəʊf-/Definition of trophoblast noun Embryology a layer of tissue on the outside of a mammalian blastula, supplying the embryo with nourishment and later forming the major part of the placenta. Derivatives trophoblastic adjective trophoblast in other Oxford dictionaries Definition of trophoblast in the US English dictionary