tris1Pronunciation: /trɪs/ (also tris buffer)Definition of tris noun [mass noun] a flammable compound which forms a corrosive solution in water and is used as a buffer and emulsifying agent. Alternative name: trishydroxymethylaminomethane; chemical formula: (HOCH2)3CNH2 Origin: 1950s: from tris-, the prefix of the systematic nametris in other Oxford dictionaries Definition of tris in the US English dictionary