trimethoprimPronunciation: /trʌɪˈmɛθə(ʊ)prɪm/Definition of trimethoprim noun [mass noun] Medicine a synthetic antibiotic used to treat malaria and respiratory and urinary infections (usually in conjunction with a sulphonamide). Origin: 1960s: from trimeth(yl) + o(xy-) + p(y)rim(idine)trimethoprim in other Oxford dictionaries Definition of trimethoprim in the US English dictionary