tricyclicPronunciation: /trʌɪˈsʌɪklɪk/Definition of tricyclic adjective Chemistry (of a compound) having three rings of atoms in its molecule. noun (usually tricyclics) Medicine any of a class of antidepressant drugs having molecules with three fused rings. Origin: late 19th century: from tri- 'three' + Greek kuklos 'circle' + -ictricyclic in other Oxford dictionaries Definition of tricyclic in the US English dictionary