tolbutamidePronunciation: /tɒlˈbjuːtəmʌɪd/Definition of tolbutamide noun [mass noun] Medicine a synthetic compound used to lower blood sugar levels in the treatment of diabetes. Alternative name: 1-butyl-3-tosylurea; chemical formula: C12H18N2O3S Origin: 1950s: from tol(uene) + but(yl) + amidetolbutamide in other Oxford dictionaries Definition of tolbutamide in the US English dictionary