thiopentonePronunciation: /ˌθʌɪə(ʊ)ˈpɛntəʊn/Definition of thiopentone noun [mass noun] Medicine a sulphur-containing barbiturate drug used as a general anaesthetic and hypnotic, and (reputedly) as a truth drug. Origin: 1940s: from thio- + a contraction of pentobarbitonethiopentone in other Oxford dictionaries Definition of thiopentone in the US English dictionary