tetralogyPronunciation: /tɪˈtralədʒi/Definition of tetralogy noun (plural tetralogies) 1a group of four related literary or operatic works. a series of four ancient Greek dramas, three tragic and one a comedy featuring a chorus of satyrs, originally presented together. 2 Medicine a set of four related symptoms or abnormalities frequently occurring together. tetralogy in other Oxford dictionaries Definition of tetralogy in the US English dictionary