tacrinePronunciation: /ˈtakriːn/Definition of tacrine noun [mass noun] Medicine a synthetic drug used in Alzheimer’s disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function. An acridine derivative; chemical formula: C13H15N2Cl Origin: 1960s: from t(etra-) + acr(id)inetacrine in other Oxford dictionaries Definition of tacrine in the US English dictionary