sulphasalazinePronunciation: /ˌsʌlfəˈsaləziːn/ (US sulfasalazine)Definition of sulphasalazine noun [mass noun] Medicine a sulphonamide antibiotic used to treat ulcerative colitis and Crohn’s disease. Origin: 1960s: from sulpha- + sal(icylic acid) + azinesulphasalazine in other Oxford dictionaries Definition of sulphasalazine in the US English dictionary