sucralfatePronunciation: /ˈs(j)uːkr(ə)lˌfeɪt/Definition of sucralfate noun [mass noun] Medicine a drug used in the treatment of gastric and duodenal ulcers. It is a complex of aluminium hydroxide and a sulphate derivative of sucrose. Origin: 1960s: blend of sucrose, aluminium, and sulfate (see sulphate)sucralfate in other Oxford dictionaries Definition of sucralfate in the US English dictionary