spondylosisPronunciation: /ˌspɒndɪˈləʊsɪs/Definition of spondylosis noun [mass noun] Medicine a painful condition of the spine resulting from the degeneration of the intervertebral discs. Origin: early 20th century: from Greek spondulos 'vertebra' + -osisspondylosis in other Oxford dictionaries Definition of spondylosis in the US English dictionary