spironolactonePronunciation: /ˌspʌɪrənə(ʊ)ˈlaktəʊn/Definition of spironolactone noun [mass noun] Medicine a steroid drug which promotes sodium excretion and is used in the treatment of certain types of oedema and hypertension. Origin: 1960s: from spiro-1 (sense 2) + lactone, with the insertion of -onespironolactone in other Oxford dictionaries Definition of spironolactone in the US English dictionary
