sotolPronunciation: /ˈsəʊtəʊl/Definition of sotol noun [mass noun] a North American desert plant of the agave family, with spiny-edged leaves and small white flowers. Genus Dasylirion, family Agavaceae: several species an alcoholic drink made from the sap of the sotol plant. Origin: late 19th century: via American Spanish from Nahuatl tzotollisotol in other Oxford dictionaries Definition of sotol in the US English dictionary