sixteenPronunciation: /sɪksˈtiːn, ˈsɪkstiːn/Translate sixteen | into French | into German | into Italian | into Spanish Definition of sixteen number equivalent to the product of four and four; one more than fifteen, or six more than ten; 16:sixteen miles east of Dublin sixteen of our eighteen patients (Roman numeral: xvi or XVI) a size of garment or other merchandise denoted by sixteen. sixteen years old:a daughter of sixteenDerivatives sixteenth number Origin: Old English siextīene (see six, -teen)sixteen in other Oxford dictionaries Definition of sixteen in the US English dictionary