simplexPronunciation: /ˈsɪmplɛks/Definition of simplex adjective technical composed of or characterized by a single part or structure. (of a communication system, computer circuit, etc.) only allowing transmission of signals in one direction at a time. noun a simple or uncompounded word. Origin: late 16th century: from Latin, literally 'single', variant of simplus 'simple'simplex in other Oxford dictionaries Definition of simplex in the US English dictionary