sextupletPronunciation: /ˈsɛkstjʊplɪt, sɛksˈtjuːplɪt/Definition of sextuplet noun 1each of six children born at one birth: only two other sets of sextuplets have been born in Britain 2 Music a group of six notes to be performed in the time of four. Origin: mid 19th century: from sextuple, on the pattern of words such as tripletsextuplet in other Oxford dictionaries Definition of sextuplet in the US English dictionary