scrapiePronunciation: /ˈskreɪpi/Definition of scrapie noun [mass noun] a disease of sheep involving the central nervous system, characterized by a lack of coordination causing affected animals to rub against trees and other objects for support, and thought to be caused by a virus-like agent such as a prion. Origin: early 20th century: from the verb scrape + -iescrapie in other Oxford dictionaries Definition of scrapie in the US English dictionary