sclerotomePronunciation: /ˈsklɪərə(ʊ)təʊm, ˈsklɛ-/Definition of sclerotome noun Embryology the part of each somite in a vertebrate embryo giving rise to bone or other skeletal tissue. Compare with dermatome, myotome.sclerotome in other Oxford dictionaries Definition of sclerotome in the US English dictionary