scleroticPronunciation: /sklɪəˈrɒtɪk, sklə-/Definition of sclerotic adjective 1 Medicine of or having sclerosis. 2becoming rigid and unresponsive; losing the ability to adapt:sclerotic management 3 Anatomy relating to the sclera. noun another term for sclera.sclerotic in other Oxford dictionaries Definition of sclerotic in the US English dictionary