sassafrasPronunciation: /ˈsasəfras/Definition of sassafras noun a deciduous North American tree with aromatic leaves and bark. The leaves are infused to make tea or ground into filé. Sassafras albidum, family Lauraceae [mass noun] an extract of the leaves or bark of the sassafras, used medicinally or in perfumery. Origin: late 16th century: from Spanish sasafrás, based on Latin saxifraga 'saxifrage'sassafras in other Oxford dictionaries Definition of sassafras in the US English dictionary