ranitidinePronunciation: /raˈnɪtɪdiːn, -ˈnʌɪt-/Definition of ranitidine noun [mass noun] Medicine a synthetic compound with antihistamine properties, used to treat ulcers and related conditions. Origin: 1970s: blend of furan and nitro-, + -ide + -ine4ranitidine in other Oxford dictionaries Definition of ranitidine in the US English dictionary