quirePronunciation: /kwʌɪə/Definition of quire noun four sheets of paper or parchment folded to form eight leaves, as in medieval manuscripts. any collection of leaves one within another in a manuscript or book: the scribe numbered the quires of his manuscript as well as the leaves 25 (formerly 24) sheets of paper; one twentieth of a ream: [as partitive]: (a quire of/quires of)the package contained two quires of tracing paperOrigin: Middle English: from Old French quaier, from Latin quaterni 'set of four'quire in other Oxford dictionaries Definition of quire in the US English dictionary