pyridostigminePronunciation: /ˌpɪrɪdə(ʊ)ˈstɪgmiːn/Definition of pyridostigmine noun [mass noun] Medicine a synthetic compound related to neostigmine, with similar but weaker and longer-acting effects. Origin: 1950s: blend of pyridine and neostigminepyridostigmine in other Oxford dictionaries Definition of pyridostigmine in the US English dictionary