pyodermaPronunciation: /ˌpʌɪə(ʊ)ˈdəːmə/Definition of pyoderma noun [mass noun] Medicine a skin infection with formation of pus. Origin: 1930s: from Greek puo- (from puon 'pus') + derma 'skin'pyoderma in other Oxford dictionaries Definition of pyoderma in the US English dictionary