pufferPronunciation: /ˈpʌfə/Definition of puffer noun 1a person or thing that puffs. chiefly Scottish a steamboat, especially a small coastal freighter: that colourful Clyde puffer, the Vital Spark informal a steam train. informal an aerosol inhaler used for administering a drug for a condition such as asthma. 2short for pufferfish.puffer in other Oxford dictionaries Definition of puffer in the US English dictionary