pruritusPronunciation: /prʊˈrʌɪtəs/Definition of pruritus noun [mass noun] Medicine severe itching of the skin, as a symptom of various ailments. Derivatives pruriticPronunciation: /-ˈrɪtɪk/ adjective Origin: mid 17th century: from Latin, 'itching' (see prurigo)pruritus in other Oxford dictionaries Definition of pruritus in the US English dictionary