protoplasmPronunciation: /ˈprəʊtə(ʊ)ˌplaz(ə)m/Definition of protoplasm noun [mass noun] Biology the colourless material comprising the living part of a cell, including the cytoplasm, nucleus, and other organelles. Derivatives protoplasmicPronunciation: /-ˈplazmɪk/ adjective Origin: mid 19th century: from Greek prōtoplasma (see proto-, plasma)protoplasm in other Oxford dictionaries Definition of protoplasm in the US English dictionary