proteolysisPronunciation: /ˌprəʊtɪˈɒlɪsɪs/Definition of proteolysis noun [mass noun] Biochemistry the breakdown of proteins or peptides into amino acids by the action of enzymes. Derivatives proteolyticPronunciation: /-əˈlɪtɪk/ adjective proteolyticallyPronunciation: /-əˈlɪtɪk(ə)li/ adverb Origin: late 19th century: modern Latin, from protein + -lysisproteolysis in other Oxford dictionaries Definition of proteolysis in the US English dictionary