prostacyclinPronunciation: /ˌprɒstəˈsʌɪklɪn/Definition of prostacyclin noun [mass noun] Biochemistry a compound of the prostaglandin type produced in arterial walls, which functions as an anticoagulant and vasodilator. Origin: 1970s: from prostaglandin + cyclic + -in1prostacyclin in other Oxford dictionaries Definition of prostacyclin in the US English dictionary