progestogenPronunciation: /prə(ʊ)ˈdʒɛstədʒ(ə)n/Definition of progestogen noun Biochemistry a natural or synthetic steroid hormone, such as progesterone, that maintains pregnancy and prevents further ovulation during pregnancy. Origin: 1940s: from progestin + -genprogestogen in other Oxford dictionaries Definition of progestogen in the US English dictionary