prochlorperazinePronunciation: /ˌprəʊklɔːˈpɛrəziːn/Definition of prochlorperazine noun [mass noun] Medicine a synthetic compound derived from phenothiazine, used as a tranquillizer. Origin: 1950s: from pro(pyl) + chlor(ine) + (pi)perazineprochlorperazine in other Oxford dictionaries Definition of prochlorperazine in the US English dictionary