primaquinePronunciation: /ˈprʌɪməkwiːn, ˈpriːmə-/Definition of primaquine noun [mass noun] Medicine a synthetic compound derived from quinoline, used in the treatment of malaria. Origin: 1940s: apparently from Latin prima (feminine of primus 'first') + quin(olin)eprimaquine in other Oxford dictionaries Definition of primaquine in the US English dictionary