porphyriaPronunciation: /pɔːˈfɪrɪə/Definition of porphyria noun [mass noun] Medicine a rare hereditary disease in which there is abnormal metabolism of the blood pigment haemoglobin. Porphyrins are excreted in the urine, which becomes dark; other symptoms include mental disturbances and extreme sensitivity of the skin to light. Origin: 1920s: modern Latin, from porphyrinporphyria in other Oxford dictionaries Definition of porphyria in the US English dictionary