polypeptidePronunciation: /ˌpɒlɪˈpɛptʌɪd/Definition of polypeptide noun Biochemistry a linear organic polymer consisting of a large number of amino-acid residues bonded together in a chain, forming part of (or the whole of) a protein molecule: [as modifier]:a polypeptide chainOrigin: early 20th century: from poly- 'many' + peptone + -idepolypeptide in other Oxford dictionaries Definition of polypeptide in the US English dictionary