plicaPronunciation: /ˈplɪkə, ˈplʌɪkə/Definition of plica noun 1 (plural plicae /-kiː/ or plicas) Anatomy a fold or ridge of tissue. Botany a small lobe between the petals of a flower. 2 [mass noun] Medicine a densely matted condition of the hair. Origin: mid 17th century: modern Latin, from medieval Latin, 'fold', from plicare 'to fold'plica in other Oxford dictionaries Definition of plica in the US English dictionary