picrotoxinPronunciation: /ˌpɪkrə(ʊ)ˈtɒksɪn/Definition of picrotoxin noun [mass noun] Medicine a bitter compound used to stimulate the respiratory and nervous system, especially in treating barbiturate poisoning. This toxin is obtained from the seeds of the shrub Anamirta cocculus (family Menispermaceae) Origin: mid 19th century: from Greek pikros 'bitter' + toxinpicrotoxin in other Oxford dictionaries Definition of picrotoxin in the US English dictionary